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Ibritumomab tiuxetan, a radioactive yttrium-90-conjugated monoclonal antibody to CD20, has demonstrated therapeutic efficacy with durable responses and allows delivery of ionizing radiation directly to the tumor site, while minimizing toxicity to normal tissue.
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Infliximab, a chimeric human-murine anti-TNFα monoclonal antibody, is widely used for the treatment of inflammatory bowel disease (IBD).
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Ipilimumab (MDX-010), a humanized monoclonal antibody against CTLA-4, causes enhanced T-cell reaction, antitumor response, and significant improvement of the overall survival of patients with metastatic melanoma.
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Bevacizumab (Avastin), an antiangiogenic anti-VEGF-R monoclonal antibody specifically binds to all VEGF-A isoforms with high affinity, has a rapid impact on tumor-related brain edema in recurrent GB.
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Brentuximab vedotin (SGN-35), a CD30-directed antibody-drug conjugate composed of an anti-CD30 monoclonal antibody linked to the microtubule-disrupting agent, is approved for treating certain patients with CD30-expressing hematologic malignancies.
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